Changelog

Version 1.0

  • Implementation of freezing model for the freezing stage in freeze-drying of a batch of vials on a shelf in python

  • Currently supported features:
    • Simulation of the freezing process, i.e. of thermal evolution and of ice formation, for a batch with arbitrary number of vials

    • Arbitrary cooling protocols (i.e., user may choose cooling rate, integrate holding steps and controlled nucleation)

    • Tracking of nucleation times, nucleation temperatures and solidification times for all vials

    • Stochastic nucleation in the form of a Monte Carlo approach as well as controlled nucleation in the form of forced initiation of nucleation at a certain point

    • Cubic geometry of vial and rectangular arrangement on the shelf